Fig. 4: Somatic HIF1A duplication was identified in cardiac tumors of Patient-1 by aCGH | Cell Death Discovery

Fig. 4: Somatic HIF1A duplication was identified in cardiac tumors of Patient-1 by aCGH

From: Combined effects of FH (E404D) and ACOX2 (R409H) cause metabolic defects in primary cardiac malignant tumor

Fig. 4: Somatic HIF1A duplication was identified in cardiac tumors of Patient-1 by aCGHThe alternative text for this image may have been generated using AI.

a Seven somatic CNVs including 42 genes were identified by aCGH (14q23.1–23.2,17p13.2, 5q35.2, 9p21.3, 14q24.2, 14p12, 16p12.2, and 16p13.3). b A larger fragment of somatic duplication including HIF1A on locus 14q23.1-23.2 was identified in both Chip-2 and Chip-3. N adjacent normal tissue, C control for reference labeling, T tumor tissue. c HIF1A expression in cardiac tumor tissues was markedly upregulated. GAPDH served as a loading control. Representative image from three independent experiments was displayed

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