Table 2 Gene expression of the TCA cycle genes was entirely downregulated in tumor tissues of both Patient-1 and -2 via whole-transcriptome analysis

CS

Citrate synthase

0.28

0.45

ACO1

Aconitase 1, soluble

NA

0.77

ACO2

Aconitase 2, mitochondrial

0.031

0.17

IDH1

Isocitrate dehydrogenase 1 (NADP+), soluble

3.27

2.11

IDH2

Isocitrate dehydrogenase 2 (NADP+), mitochondrial

0.21

0.52

IDH3A

Isocitrate dehydrogenase 3 (NAD+) alpha

0.13

0.28

IDH3B

Isocitrate dehydrogenase 3 (NAD+) beta

0.26

0.49

IDH3G

Isocitrate dehydrogenase 3 (NAD+) gamma

1.09

0.65

OGDH

Oxoglutarate (alpha-ketoglutarate) dehydrogenase

0.18

0.19

OGDHL

Oxoglutarate dehydrogenase-like

0.12

0.12

DLD

Dihydrolipoamide dehydrogenase

0.11

0.45

DLST

Dihydrolipoamide S-succinyltransferase

0.43

0.68

SUCLG1

Succinate-CoA ligase, alpha subunit

0.30

0.38

SUCLG2

Succinate-CoA ligase, GDP-forming, beta subunit

0.22

0.57

SUCLA2

Succinate-CoA ligase, ADP-forming, beta subunit

0.12

0.39

SDHA

Succinate dehydrogenase complex, subunit A,

0.10

0.46

SDHB

Succinate dehydrogenase complex, subunit B,

0.19

0.33

SDHC

Succinate dehydrogenase complex, subunit C,

0.39

0.63

SDHD

Succinate dehydrogenase complex, subunit D,

NA

0.63

FH

Fumarate hydratase

0.20

0.22

MDH1

Malate dehydrogenase 1, NAD (soluble)

0.091

0.20

MDH2

Malate dehydrogenase 2, NAD (mitochondrial)

0.17

2.35

GOT1

Glutamic-oxaloacetic transaminase 1, soluble

0.047

0.13

GOT2

Glutamic-oxaloacetic transaminase 2, mitochondrial

0.16

0.22