Table 3 Glucose metabolism was mostly switched from glycolysis to pentose phosphate pathway in both patients

From: Combined effects of FH (E404D) and ACOX2 (R409H) cause metabolic defects in primary cardiac malignant tumor

Gene name

Fold-change (tumor/normal)

 

Patient-1

Patient-2

Glycolysis⇒PPP pathway

HK1

Hexokinase 1

0.24

0.45

HK2

Hexokinase 2

3.38

1.67

HK3

Hexokinase 3

21.30

1.89

PFKM

Phosphofructokinase, muscle

0.12

0.16

FBP1

Fructose-1,6-bisphosphatase 1

60.13

1.43

G6PD

Glucose-6-phosphate dehydrogenase

7.13

3.20

PGLS

6-Phosphogluconolactonase

4.74

1.98

PGD

Phosphogluconate dehydrogenase

2.49

7.17

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