Fig. 6: The signaling network provide more detailed characteristics for age-associated genes.
From: An analysis of aging-related genes derived from the Genotype-Tissue Expression project (GTEx)
a The proportion of positive and negative links in out-degree. UAGs have greater number of positive links than DAGs. b Greater number of negative links in in-degree of UAGs as compared with DAGs. *P < 0.05, ***P < 0.001 from chi-squared test. c, d Box plots present the difference in c betweenness centrality and d closeness centrality between groups in signaling networks. e The network distances revealed by average of the shortest paths are shown in boxplot. *P < 0.05, **P < 0.01, ***P < 0.001 from Wilcoxon test
