Table 1 Statistical results for characteristic analyses in evolution and expression

From: An analysis of aging-related genes derived from the Genotype-Tissue Expression project (GTEx)

 

DAGs versus UAGs

DAGs versus NAGs

UAGs versus NAGs

dN/dS

 Median

U: 0.22

D: 0.09

N: 0.16

 W-value

227,110

2,243,300

3,179,700

 P-value

1.43e-50

5.02e-45

5.11e-12

Homologous gene number

 Median

U: 9

D: 12

N: 10

 W-value

155,150

9,421,800

5,009,300

 P-value

5.73e-55

3.39e-60

7.05e-9

Phyletic evolution

 Chi-square

121.64

160.46

24.01

 P-value

7.37e-24

4.74e-32

5.21e-4

Average expression level

 Median

U: 29,873.5

D: 42,838

N: 27,993

 W-value

196,500

7,431,900

4,885,500

 P-value

2.91e-13

2.41e-37

0.032

Tissue specificity

 Median

U: 0.24

D: 0.19

N: 0.21

 W-value

349,390

4,727,100

5,389,400

 P-value

2.27e-31

2.73e-20

1.24e-11

Earliest expression stage

 Chi-square

149.99

164.91

19.266

 P-value

7.77e-30

5.39e-33

0.0037

Essential genes

 Proportion

U: 11.83% (84 of 710)

D: 15.30% (132 of 863)

N: 11.92% (2248 of 18,855)

 Chi-square

3.67

8.53

2.23e-4

 P-value

0.06

3.49e-3

0.99

  1. dN/dS ratio, homologous gene number and expression pattern were analyzed by Wilcoxon test, the phyletic evolution, earliest expression stage and essential genes enrichment analyses were performed by chi-squared test
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