Fig. 6: Kindlin-2 deficiency attenuates mouse liver fibrosis following CCl4 treatment.
From: Kindlin-2 regulates hepatic stellate cells activation and liver fibrogenesis
WT and Kindlin-2+/− mice (n = 6–8 in each group) underwent CCl4 injection for 6 weeks. a Liver fibrosis was evaluated by H&E, Sirius Red, and Masson’s trichrome staining. Scale bars = 200 μm. b Western blot analysis of Kindlin-2 in livers from WT and Kindlin-2+/− mice. The right panels show quantitative analyses of Kindlin-2 expression after normalization with β-actin. c Representative western blot analysis of α-SMA expressions in the livers from WT and Kindlin-2+/− mice. The right panels show quantitative analyses of α-SMA expression after normalization with β-actin. d The mRNA expressions of col1a1, col1a2, and col3a1 were determined by real-time PCR. *p < 0.05, **p < 0.01, ***p < 0.001
