Fig. 1: ATX reverses Hcy-induced neuronal toxicity. | Cell Death Discovery

Fig. 1: ATX reverses Hcy-induced neuronal toxicity.

From: Reversal of homocysteine-induced neurotoxicity in rat hippocampal neurons by astaxanthin: evidences for mitochondrial dysfunction and signaling crosstalk

Fig. 1

a Neural toxicity of Hcy towards primary neurons. Neurons were treated with 1–10 mM Hcy for 24 h, and neural viability was detected by CCK-8 assay. b ATX reversed Hcy-induced neural toxicity. Neurons were pre-treated with 0.5–5 μM ATX before Hcy co-treatment. c Morphological changes. Neural morphological changes with or without tubulin staining were observed by phase contrast and fluorescence microscope (magnification, ×200). All data and images were obtained from three random experiments. Scale bar in figures indicates 50 μm. Bars with “*”, “**” and “***” represent the P < 0.05, P < 0.01 and P < 0.001, respectively. Bars with different letters indicate the statistic difference at P < 0.05

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