Table 5 The activity level of caspase-3 in polycystic kidney epithelial cells

From: Low-dose 2-deoxyglucose and metformin synergically inhibit proliferation of human polycystic kidney cells by modulating glucose metabolism

 

Control

2-DG

MET

2-DG+MET

12 h

1.00 ± 0.04

1.01 ± 0.04

1.00 ± 0.04

1.14 ± 0.02***

24 h

1.00 ± 0.05

1.02 ± 0.03

1.00 ± 0.04

1.13 ± 0.03***

36 h

1.00 ± 0.06

1.21 ± 0.07***

1.00 ± 0.04

1.38 ± 0.09***

48 h

1.00 ± 0.03

1.35 ± 0.04***

1.00 ± 0.06

1.57 ± 0.03***

  1. Control: normal group, 2-DG 2-deoxyglucose-alone group, MET metformin alone group, 2-DG+MET the combination of 2-DG and metformin
  2. ***p < 0.001 vs Control
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