Fig. 2: LPS regulates Notch signaling in primary astrocytes.
From: Notch signaling in astrocytes mediates their morphological response to an inflammatory challenge
a LPS treatment induces the transcription of the ligand Jagged-1, while reduces the expression of the receptor Notch-1 and the effector Hes-5. *, **, *** significant differences (p < 0.05, p < 0.01, and p < 0.001) versus control (Student’s t-test, n = 4). b–e The NFκB inhibitor BAY-1 is able to significantly reduce the LPS-induced increase in the transcription of IL-6, IP-10, and Jag-1 (b–d) and decrease of Hes-5 (e). f LPS downregulation on Notch-1 transcription is not modified by BAY-11. Statistical significance was determined using one-way ANOVA and Bonferroni post hoc test; *, **, ***significant differences (p < 0.05, p < 0.01, and p < 0.001) versus control. $significant differences (p < 0.05) versus LPS
