Fig. 8: Summary of the effects of LPS and IGF-1 on Notch signaling in astrocytes.
From: Notch signaling in astrocytes mediates their morphological response to an inflammatory challenge
a Inflammatory conditions in primary astrocytes: LPS activates NFκB that promotes the expression of (1) molecules that generate inflammation and (2) the Notch ligand Jag-1 that reduces Notch activity and consequently induce a reactive morphology in astrocytes. b Anti-inflammatory conditions in primary astrocytes: IGF-1 produces an increase of Notch activity by: (1) activating MAPK signaling pathway and (2) reducing Jag-1 NFκB-dependent expression. Both IGF-1 effects drive to enhance Hes-5 expression and result in a resting morphology in astrocytes
