Fig. 2: Hyperglycemia enhances KC-related inflammation response posttreated with APAP. | Cell Death Discovery

Fig. 2: Hyperglycemia enhances KC-related inflammation response posttreated with APAP.

From: Hyperglycemia exacerbates acetaminophen-induced acute liver injury by promoting liver-resident macrophage proinflammatory response via AMPK/PI3K/AKT-mediated oxidative stress

Fig. 2: Hyperglycemia enhances KC-related inflammation response posttreated with APAP.

Hyperglycemic (streptozotocin, STZ) and control (CON) mice were prepared as described in “Materials and methods” section. a APAP-induced acute liver injury or a sham procedure was performed. Inflammatory gene expression in liver was measured by quantitative RT-PCR (n = 6/group). b Serum levels of inflammatory cytokines were measured by ELISA (n = 6/group). c-h F4/80 + macrophages, CD11b + macrophages, and Ly6G + neutrophils infltration in liver was detected by immunohistochemical staining (original magnification ×200). Representative of six mice/group. Quantification of F4/80 + macrophages, CD11b + macrophages, and Ly6G + neutrophils per high power field (×200) (n = 6/group) (mean ± SD, *p < 0.05)

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