Fig. 3: MHT increases autophagic flux in mice after CA/CPR and in neurons after OGD/R for 12 h. | Cell Death Discovery

Fig. 3: MHT increases autophagic flux in mice after CA/CPR and in neurons after OGD/R for 12 h.

From: Mild hypothermia improves neurological outcome in mice after cardiopulmonary resuscitation through Silent Information Regulator 1-actviated autophagy

Fig. 3: MHT increases autophagic flux in mice after CA/CPR and in neurons after OGD/R for 12 h.The alternative text for this image may have been generated using AI.

a MHT increases transcription of a subset of autophagic gene (AMBRA1, ATG10, ATG1L1, ATG4B, CXCR4, BECLIN1, GAA, MAPLC3A, MAPLC3B, PIK3C3, ATG5, ATG7, ATG12) in cortex of mice after ROSC for 12 h. b MHT increases autophagic flux in the cortex of mice after ROSC for 12 h. c MHT increases expression of a subset of autophagic genes (AMBRA1, ATG10, ATG1L1, ATG4B, CXCR4, BECLIN1, GAA, MAPLC3A, MAPLC3B, PIK3C3, ATG5, ATG7, ATG12) in cultured cortical neurons after OGD/R for 12 h. d MHT increases autophagic flux in cultured cortical neurons after OGD/R for 12 h. e MHT increases the number of red and yellow puncta in cultured neurons after OGD/R for 12 h. *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001, vs. respective control groups as indicated

Back to article page