Fig. 4: Suppression of Sirt1 reduces the MHT-induced increase in expression of LC3B and decrease in p-P53 level both in vivo and in vitro. | Cell Death Discovery

Fig. 4: Suppression of Sirt1 reduces the MHT-induced increase in expression of LC3B and decrease in p-P53 level both in vivo and in vitro.

From: Mild hypothermia improves neurological outcome in mice after cardiopulmonary resuscitation through Silent Information Regulator 1-actviated autophagy

Fig. 4: Suppression of Sirt1 reduces the MHT-induced increase in expression of LC3B and decrease in p-P53 level both in vivo and in vitro.The alternative text for this image may have been generated using AI.

a Sirt1 knockout attenuates the MHT-induced increase in LC3B expression and decrease in p-P53 level in cortex of mice. b Western blot showing Sirt1 knockdown efficiency by siSirt1 and siSirt2 in cultured neurons. GAPDH is used as a loading control. c Sirt1 knockdown increases p-P53 in cultured neurons. d Sirt1 knockdown blocks the autophagic flux in NT or MHT treated neurons after OGD/R. *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001, vs. respective control group as indicated

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