Fig. 6: Suppression of autophagy attenuates MHT-reduced neuron death after OGD/R. | Cell Death Discovery

Fig. 6: Suppression of autophagy attenuates MHT-reduced neuron death after OGD/R.

From: Mild hypothermia improves neurological outcome in mice after cardiopulmonary resuscitation through Silent Information Regulator 1-actviated autophagy

Fig. 6

a Western blot showing the efficiency in P53 knockdown by siRNAs in cultured neurons. b P53 knockdown has no significant effect on neuron survival after OGD/R for 24 h. c 3-MA inhibits autophagy in cultured neurons. d 3-MA treatment increases neuron death and abolishes neuroprotection by MHT after OGD/R for 24 h. *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001, vs. respective control as indicated

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