Fig. 5: SEMGs induce apoptosis and sensitize cells to genotoxic drugs. | Cell Death Discovery

Fig. 5: SEMGs induce apoptosis and sensitize cells to genotoxic drugs.

From: Cancer-testis antigens, semenogelins 1 and 2, exhibit different anti-proliferative effects on human lung adenocarcinoma cells

Fig. 5: SEMGs induce apoptosis and sensitize cells to genotoxic drugs.The alternative text for this image may have been generated using AI.

MTT assay of H1299 cells overexpressing vector, SEMG1, SEMG2 and incubated with different concentrations of a doxorubicin or b cisplatin. c MTT assay of H1299 cells with scramble or SEMG2 knockdown (KD) treated with cisplatin. Knockdown of SEMG2 is visualized by western-blotting. d Apoptosis profile of non-treated or treated with 30 μM of cisplatin or 75 μM of etoposide H1299 cells overexpressing vector, SEMG1 or SEMG2. e Percentage of apoptosis increase in H1299 cells with vector, SEMG1 or SEMG2 overexpressing after treatment with etoposide or cisplatin. Results are represented as mean ± SEM of three experiments. **P < 0.01.

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