Fig. 5: MEK5 is required for differentiation and mitophagy in erythroid progenitors. | Cell Death Discovery

Fig. 5: MEK5 is required for differentiation and mitophagy in erythroid progenitors.

From: MEKK3-MEK5-ERK5 signaling promotes mitochondrial degradation

Fig. 5

a Murine erythroid progenitors were treated with the BIX02188 (30 μM) or vehicle control (DMSO) prior to initiation of differentiation. Levels of CD71 and Ter119 were measured by flow cytometry. Representative profiles are shown. b Mitochondrial mass was quantified in Ter119+CD71high and Ter119+CD71low erythroblasts using median fluorescence intensity (MFI) of MitoTracker Deep Red FM. The data represent three replicates. ***P < 0.001.

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