Fig. 2: Astrocyte-overexpressed hepcidin alleviated Aβ-induced apoptosis in the mouse brain. | Cell Death Discovery

Fig. 2: Astrocyte-overexpressed hepcidin alleviated Aβ-induced apoptosis in the mouse brain.

From: Hepcidin overexpression in astrocytes alters brain iron metabolism and protects against amyloid-β induced brain damage in mice

Fig. 2: Astrocyte-overexpressed hepcidin alleviated Aβ-induced apoptosis in the mouse brain.

a TUNEL-positive cells (green) and DAPI-stained nuclei in the cortex near lateral ventricles and hippocampal CA3 regions of mice in different groups were observed. Bar = 50 μm. b, c The statistical analysis of relative apoptotic cell levels in cortical sections (b) and hippocampal sections (c). Data are presented as the means ± SEM, n = 6. d, e Western blot was used to detect expression levels of Bcl-2 and Bax in the cortex (d) and hippocampus (e) in different groups of mice, and the ratios of Bcl-2/Bax were calculated and expressed as fold of control. Data are presented as the means ± SEM, n = 6. *P < 0.05 and **P < 0.01.

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