Fig. 4: Astrocyte hepcidin ameliorated Aβ-induced elevation in iron levels. | Cell Death Discovery

Fig. 4: Astrocyte hepcidin ameliorated Aβ-induced elevation in iron levels.

From: Hepcidin overexpression in astrocytes alters brain iron metabolism and protects against amyloid-β induced brain damage in mice

Fig. 4: Astrocyte hepcidin ameliorated Aβ-induced elevation in iron levels.

a, b Detection of brain iron distribution by synchrotron radiation μ-XRF in the cortex (a) and hippocampus (b). The iron content in the blue region is the lowest, and increases gradually from blue to red, while the iron content in the red region is the highest. c, d Western blot was used to measure L-ferritin in the cortex (c) and hippocampus (d) of mice in different groups. The relative expression levels in different groups as compared to the control group were calculated after normalizing each specific band to its respective β-actin band, and are presented as means ± SEM, n = 6. *P < 0.05 and **P < 0.01.

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