Table 1 Caspase-3-dependent cell death patterns in tumors.
From: The caspase-3/GSDME signal pathway as a switch between apoptosis and pyroptosis in cancer
Drugs | Cancer types | Mechanism | Ref |
|---|---|---|---|
Cisplatin and Paclitaxel | Lung cancer | Activate caspase-3/GSDME | |
Piperlongumine analogue L50377 | Lung cancer | Promote ROS and activate | |
Chalcone analogue | Lung cancer | Promote ROS and activate caspase-3/GSDME-mediated pyroptosis | |
Thiopyran derivative L61H10 | Lung cancer | Cause an apoptosis-to-pyroptosis switch via NF-κB/GSDME | |
BRAFi + MEKi | Melanoma | Activate caspase-3/GSDME | |
Doxorubicin | Melanoma | Activate caspase-3/GSDME-mediated puroptosis via eEF-2K | |
iron | Melanoma | Activate Tom 20/Bax/cytochrome c/caspase-3/GSDME | |
Shikonin | Melanoma | Induce apoptosis by activating caspase-3 | |
Houttuynia cordata Thunb | Melanoma | Cause the activation of caspase-8/3 and p38/MAPK | |
Dioscin | Osteosarcoma | Activate caspase-3/GSDME and upregulate cytochrome c/Bax | |
miR-143 | Osteosarcoma | Target the Bcl-2 directly and activate caspase-3 | |
Pachymic acid | Osteosarcoma | Induce apoptosis by activating caspase-3 | |
Loboplatin | Colon cancer | Promote ROS/JNK/Bax/cytochrome c mitochondrial apoptosis pathway and activate caspase-3/GSDME | |
PTBP1 | Colon cancer | Upregulate Bax/cytochrome c/p53 and caspase-3/PARP1 | |
Bufalin | Colon cancer | Promote ROS and activate caspase-3 | |
TNFα + CHX and navitoclax | Colon cancer | Through a BAK/BAX-caspase-3-GSDME signaling pathway to promote GSDME-C terminal to be palmitoylated, and induce pyroptosis | |
5-Fu | Gastric cancer | Activate caspase-3/GSDME | |
Silibinin | Gastric cancer | Activate caspase-3 and induce endogenous apoptotic pathways through the mitochondria | |
PLK1 inhibitor BI2536 | Esophageal cancer | Combine with Cisplatin, activated Bax/caspase-3 and caused an apoptosis-to-pyroptosis switch via GSDME | |
Metformin | Esophageal cancer | Downregulate PKM2 and induce apoptosis by activating caspase-3/Bim | |
EGCG | Esophageal cancer | Induce apoptosis by downregulating Bcl-2 and upregulating caspase-3/Bax | |
Osthole | Ovarian cancer | Promote ROS and activate caspase-3 which induce apoptosis and pyroptosis | |
Galangin | Glioblastoma multiforme | Activate caspase-3/GSDME Combine with chloroquine, improved the effectiveness of cancer therapies |
