Fig. 4: High level of RAC1 is associated with reduced patient survival.
From: The ZNF750–RAC1 axis as potential prognostic factor for breast cancer
A Kaplan–Meier survival analysis showing that higher expression of RAC1 associates with a poor patient survival. The analysis was performed across several datasets of breast invasive carcinoma using cBioPortal for Cancer Genomics database, the R2 Genomic Platform (https://r2.amc.nl) and UALCAN website (http://ualcan.path.uab.edu/index.html). B Schematic representation of ZNF750 role in breast cancer. ZNF750 represses breast cancer migration and invasion by recruiting the epigenetic modifiers KDM1a and HDAC1 on CTNNAL1 and LAMB3 promoters (ref. 8). Furthermore, ZNF750 represses RAC1 expression by binding to its promoter, therefore modulating the cytoskeleton remodelling and possibly affecting migration and chemoresistance in breast cancer.
