Fig. 7: Schematic figure illustrating the mechanism of FN-EDA promoting angiogenesis in hepatic fibrosis.
From: FN-EDA mediates angiogenesis of hepatic fibrosis via integrin-VEGFR2 in a CD63 synergetic manner
In hepatic fibrosis, FN-EDA is over secreted by activated HSCs to HSECs and stimulates activation of HSECs via integrin-CD63-VEGFR2 receptor complex which leading to pathological angiogenesis.
