Fig. 3: Effects of selective and conditional expression of ∆NIκBα in insulin-producing cells during embryonic, neonatal, or adult periods on diabetes incidence in NOD/ToIβ as compared to the parental NOD/LtJ female mice. | Cell Death Discovery

Fig. 3: Effects of selective and conditional expression of ∆NIκBα in insulin-producing cells during embryonic, neonatal, or adult periods on diabetes incidence in NOD/ToIβ as compared to the parental NOD/LtJ female mice.

From: NF-κB activity during pancreas development regulates adult β-cell mass by modulating neonatal β-cell proliferation and apoptosis

Fig. 3

A Experimental design: NOD/ToIβ or NOD/LtJ female mice were exposed to Dox (0.2 mg/ml) during the embryonic period until birth (E11–P1: red line), during the neonatal period from birth to weaning (P1–P21: blue line) or after weaning (3–35 weeks) up to 35 weeks (green line). Diabetes incidence was monitored once a week until 35 weeks. B Percentage of hyperglycemic NOD/ToIβ mice in untreated (control, black line, n = 29) or Dox-treated animals during the embryonic period until birth (red line, n = 30); from birth until weaning (blue line n = 23) or D between 3 and 35 weeks (green line, n = 34). *P < 0.008 vs control. C, E Percentage of hyperglycemic mice in the parental NOD/LtJ female mice similarly treated as in B and D. C NOD/LtJ mice untreated (control, black lane n = 20); or Dox-treated animals during the embryonic period until birth (red line, n = 20); from birth until weaning (blue line n = 19). E Diabetes incidence in untreated (control; black line, n = 65) and Dox-treated animals from 3 weeks onward until the end of the follow-up at 35 weeks (green line, n = 23).

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