Table 1 The protein-protein interactions between CHIP and Arc or the downstream proteins of Wnt pathway were detected by ZDOCK server.

From: CHIP promotes Wnt signaling and regulates Arc stability by recruiting and polyubiquitinating LEF1 or Arc

Name

Accession number

Amino acids number

Template

Sequence identity (%)

Coverage range

ZDOCK score

Arc

AAF07185.1

396

6gse.1.A

97.48

206–364

1571.384

β-TrCP

NP_378663.1

605

1p22.1.A

100

175–581

1515.898

LEF1

AAH40559.1

386

2lef.1.C

98.68

270–345

1455.843

GSK3β

ABX89591.1

420

1j1b.1.B

100

23–386

1425.833

APC

AAA03586.1

2843

3nmz.1.A

100

326–736

1416.511

Rac1

CAB53579.5

192

1hh4.2.A

99.48

2–189

1409.991

Axin

AAI43245.1

778

1dk8.1.A

61.27

67–208

1338.895

CYLD

CAB93533.1

956

2vhf.1.A

100

583–956

1365.055

β-catenin

CAA61107.1

781

1v18.1.A

100

150–664

1361.005

Dvl-1

NP_001317240.1

695

1fsh.1.A

98.04

406–499

1216.274

CK1

CAA56710.1

374

6gzd.1.A

98.52

9–305

1176.247

TCF4

AAI25085

671

2ypa.1.B

81.01

561–633

1108.784

CHIP

AAH17178.1

303

2c2l.2.A

97.86

23–303

 
  1. The three-dimensional structure of proteins was obtained from an automated protein structure homology-modeling server of SWISS-MODEL. The higher ZDOCK scores were presented the stronger interactions between CHIP and proteins.
Back to article page