Fig. 3: Analysis of gene expression in MM cells after EZH2 and G9a inhibition. | Cell Death Discovery

Fig. 3: Analysis of gene expression in MM cells after EZH2 and G9a inhibition.

From: Dual EZH2 and G9a inhibition suppresses multiple myeloma cell proliferation by regulating the interferon signal and IRF4-MYC axis

Fig. 3

A Heat maps for the genes whose expression was altered in MM cell lines by the indicated drugs (1 μM each, 6 days). Shown are means of two biological replications. B Venn diagrams of genes upregulated (left) or downregulated (right) by GSK126 + UNC0638 in two MM cell lines. Genes upregulated or downregulated in both cell lines are listed in boxes on the right. C, D Gene ontology (C) and pathway analyses (D) of genes altered by GSK126 + UNC0638 (>2-fold) in MM cell lines. E GSEA of the genes involved in interferon α and β signaling using the microarray data from the indicated MM cell lines treated with DMSO or GSK126 + UNC0638.

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