Fig. 4: WHSC1 reduction suppresses CRC cell growth and promotes apoptosis in vivo.

a Tumor growth in mice injected with HCT116 cells stably expressing shWHSC1-1 or the control. b, c Tumor volume (b) and volume weight (c) in mice injected with HCT116 cells stably expressing control or shWHSC1-1 (n = 6). d, e Immunohistochemistry results for TUNEL and caspase3 assays of tumors derived from HCT116 cells stably expressing control or shWHSC1-1.