Fig. 2: The isoforms of SRA1 have different effects. | Cell Death Discovery

Fig. 2: The isoforms of SRA1 have different effects.

From: SRSF1 promotes the inclusion of exon 3 of SRA1 and the invasion of hepatocellular carcinoma cells by interacting with exon 3 of SRA1pre-mRNA

Fig. 2

A SRA1 expression levels in human HCC tissues from TCGA samples. B Design of shRNA applied to selectively target the In1, exon 3 and exon 2/exon 3 splice junctions. C CCK8 assays were carried out to examine the effect on cell proliferation of SRA1-L/S in HepG2. D, F Wound healing experiments were carried out to estimate the effects of overexpressed SRA1-L/S on the migration in HepG2. E, G Wound healing experiments were carried out to estimate the effects of knocked-down SRA1-E3, SRA1-E2E4, and SRA1-In1 on the migration in HepG2. Data are presented as mean ± S.D. (N = 3). The “*, **, ***” indicate “P < 0.05, 0.01, 0.001” versus the control group, respectively. “#, ##, ###” represents “P < 0.05, 0.01, 0.001”.

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