Fig. 3: AZD4320 enhances MPM cell killing by Cisplatin. | Cell Death Discovery

Fig. 3: AZD4320 enhances MPM cell killing by Cisplatin.

From: A novel BH3-mimetic, AZD0466, targeting BCL-XL and BCL-2 is effective in pre-clinical models of malignant pleural mesothelioma

Fig. 3: AZD4320 enhances MPM cell killing by Cisplatin.

A Cisplatin alone is less effective than AZD4320, however, the combination increases cell killing. Cell viability was determined using CellTiter-Glo assays after 72 h treatment. Data represent mean ± SEM (n = 3). B Summary of EC50 values for treatments in A. C Synergy analysis of combinations in A performed with Combenefit software using the BLISS synergy model.

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