Fig. 8: Schematic of the biological roles of circHIF1A from CAFs exosomes in breast cancer. | Cell Death Discovery

Fig. 8: Schematic of the biological roles of circHIF1A from CAFs exosomes in breast cancer.

From: Carcinoma-associated fibroblasts derived exosomes modulate breast cancer cell stemness through exonic circHIF1A by miR-580-5p in hypoxic stress

Fig. 8: Schematic of the biological roles of circHIF1A from CAFs exosomes in breast cancer.The alternative text for this image may have been generated using AI.

In hypoxia, CAFs derived exosomal circHIF1A could bind to miR-580-5p as a miRNA sponge, promoting breast cancer stem cell properties by upregulating CD44. In normoxia, the above phenotype was suppressed.

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