Table 1 Association between HIF-1α, Beclin1 expression, and the clinical as well histopathological features of patients with oral squamous cell carcinoma (n = 80).
Variables | Number of patients (n) | HIF-1a positive (n) | HIF-1a positive rate (%) | χ2 | p | Beclin1 positive (n) | Beclin1 positive rate (%) | χ2 | p |
|---|---|---|---|---|---|---|---|---|---|
Sex | |||||||||
Male | 56 | 39 | 69.6% | 0.069 | 0.966 | 39 | 69.64% | 1.372 | 0.504 |
Female | 24 | 16 | 66.67% | 19 | 79.17% | ||||
Age, years | |||||||||
≥60 | 55 | 47 | 85.45% | 1.064 | 0.587 | 43 | 78.18% | 0.9503 | 0.622 |
<60 | 25 | 19 | 76% | 17 | 68% | ||||
Tumor size, cm | |||||||||
≥1.5 | 53 | 43 | 81.13% | 6.661 | 0.037 | 42 | 79.25% | 10.87 | 0.004 |
<1.5 | 27 | 14 | 51.85% | 11 | 40.74% | ||||
TNM stage | |||||||||
I or II | 24 | 14 | 58.3% | 8.54 | 0.015 | 11 | 45.83% | 8.412 | 0.015 |
III or IV | 56 | 49 | 87.5% | 44 | 78.57% | ||||
Differentiation | |||||||||
Well | 29 | 13 | 44.83% | 8.137 | 0.017 | 12 | 41.38% | 6.572 | 0.037 |
Moderate/poor | 51 | 39 | 76.47% | 36 | 70.59% | ||||
Lymph node metastasis | |||||||||
Positive | 47 | 39 | 82.98% | 33.71 | 0.001 | 33 | 70.21% | 6.729 | 0.035 |
Negative | 33 | 7 | 21.21% | 14 | 42.42% | ||||
