Fig. 2: Schematic illustration of the regulatory mechanisms of tumor-derived Ig expression.
From: Current insights into the expression and functions of tumor-derived immunoglobulins
A The transcription factors (E2A, FOXO1, FOXP1, EBF, and Pax5) bond to Erag and other RAG promoters to activate transcription of RAG1 and RAG2, which in turn promoted V(D)J recombination of Igs in cancer cells. Finally, tumor-derived Ig expression was upregulated. B LMP1 enhanced Igκ intron enhancer activity, which in turn promoted transcription factors NF-κB (p52 and p65) binding to its corresponding motif as well as AP-1 (c-Jun and c-Fos) binding to its corresponding motif in Igκ gene in NPC cells. Finally, Igκ expression was upregulated through the activation of NF-κB and AP-1 signaling pathways.
