Fig. 3: Schematic illustration of biological functions of tumor-derived Igs.
From: Current insights into the expression and functions of tumor-derived immunoglobulins
Tumor-derived Igs are involved in the following four aspects of tumor development and progression: (1) tumor cell growth and proliferation; (2) tumor cell migration, invasion, and metastasis; (3) tumor immune escape; (4) other biological functions. Other biological functions of tumor-derived Igs are as follows: (1) immunity regulation; (2) promotion of drug resistance; (3) involvement of cancer-associated diabetes; (4) influence of tumor-associated thrombosis; (5) mediation of CSC potential; (6) regulation of cell morphogenesis, cell cycle process, fatty acid biosynthetic process, protein biosynthesis, and antimicrobial (virus, bacterium, and fungus).
