Fig. 4: Schematic illustration of the mechanisms that tumor-derived Igs promoted tumor cell growth and proliferation.
From: Current insights into the expression and functions of tumor-derived immunoglobulins
Tumor-derived Igs augmented multiple tumor cell growth and proliferation through positively or negatively regulating the following cell signaling pathways or biological processes or important molecules, including MAPK/ERK signaling pathway, MAPK/p38 signaling pathway, TLR4 signaling pathway, MEK/ERK/c-Myc signaling pathway, caspase-dependent signaling pathway, apoptosis, cell cycle, ATPase, and proliferation markers. Tumor-derived IgG specifically recognized by RP215 promoted cancer (breast cancer and LSCC) cell proliferation.
