Fig. 5: Inhibiting the release of cytokines by activated microglial cells aggravates seizures. | Cell Death Discovery

Fig. 5: Inhibiting the release of cytokines by activated microglial cells aggravates seizures.

From: Intestinal Klebsiella pneumoniae infection enhances susceptibility to epileptic seizure which can be reduced by microglia activation

Fig. 5

A Graphic representation of the intervention timeline in the animal experiment. B Representative images of IL-1β and IL-6 expression in the cortex and hippocaumps of mice treated with K. pneumoniae and GIBH-130 + K. pneumoniae respectively. C Quantification of IL-1β and IL-6 expression in the cortex and hippocaumps in two groups. Compared with that in the K. pneumoniae group, IL-1β and IL-6 expression was decreased in the cortex and hippocaumps of mice in the GIBH-130 + K. pneumoniae group (n = 3 in each group; *P < 0.05 versus controls, Student’s t test). D Percentage survival over the number of PTZ injections (n = 8 in each group; *P < 0.05, log-rank test).

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