Table1 Key resources table.

CD45, Clone 30-F11

eBioscience

Cat# 53-0451-82; RRID:AB_2848416

CD45, Clone 30-F11

eBioscience

Cat# 56-0451-82; RRID: AB_891454

CD11B, Clone M1/70

eBioscience

Cat# 45-0112-82; RRID: AB_953558

Ly6G, Clone RB6-8C5

eBioscience

Cat# 25-5931-82; RRID: AB_469663

Ly6C, Clone NK1.4

eBioscience

Cat# 12-5932-82; RRID:AB_10804510

Ly6C, Clone NK1.4

eBioscience

Cat# 62-5932-80; RRID: AB_2735067

F4/80, Clone BM8

eBioscience

Cat# 11-4801-82; RRID: AB_2637191

F4/80, Clone BM8

eBioscience

Cat# 17-4801-82; RRID: AB_2784648

CD11C, Clone N418

eBioscience

Cat# 63-0114-82; RRID:AB_2722930

CD11C, Clone HL3

BD Pharmingen™

Cat# 550261; RRID: AB_398460

CD3, Clone 17A2

eBioscience

Cat# 56-0032-82; RRID: AB_529507

NK1.1, Clone PK136

eBioscience

Cat# 12-5941-82; RRID: AB_466050

B220, Clone RA3-6B2

eBioscience

Cat# 62-0452-82; RRID: AB_2734992

CD115, Clone AFS98

eBioscience

Cat# 53-1152-82; RRID: AB_2016696

CD117, Clone 2B8

eBioscience

Cat# 62-1171-82; RRID:AB_2637141

CD117, Clone 2B8

eBioscience

Cat# 11-1171-81; RRID: AB_465185

CD135, Clone A2F10

eBioscience

Cat# 15-1351-82; RRID: AB_494219

CD135, Clone A2F10

eBioscience

Cat# 46-1351-80; RRID: AB_10733392

CD62P, Clone Psel.KO2.3

eBioscience

Cat# 12-0626-82; RRID:AB_1210863

CD29, Clone HMb1-1

eBioscience

Cat# 11-0291-80; RRID:AB_2572448

CD44, Clone IM7

eBioscience

Cat# 11-0441-81; RRID: AB_465044

CD105, Clone MJ7/18

eBioscience

Cat# 53-1051-80; RRID:AB_2815203

Sca-1, Clone D7

eBioscience

Cat# 45-5981-80; RRID: AB_914370

CD31, Clone 390

eBioscience

Cat# 46-0311-80; RRID:AB_1834430

CD34, Clone RAM34

eBioscience

Cat# 11-0341-81; RRID: AB_465020

MerTK, Clone DS5MMER

eBioscience

Cat# 63-5751-82; RRID:AB_2688139

anti-rat Fc receptor (CD16/32), Clone 2.4G2

BD Pharmingen™

Cat# 553140; RRID: AB_394655

anti-alpha smooth muscle actin Rabbit mAb

Abcam

Cat# ab5694; RRID: AB_2223021

anti-MerTK Rabbit mAb, Clone EPR17534-139

Abcam

Cat# ab184086

GAPDH Monoclonal Antibody, Clone ZG003

Invitrogen

Cat# 39-8600; RRID: AB_2533438

p44/42 MAPK (Erk1/2) Rabbit mAb

CST

Cat# 4695; RRID:AB_390779

Phospho-p44/42 MAPK (Erk1/2) Rabbit mAb

CST

Cat# 4370; RRID: AB_2315112

p-Tyr mouse mAb

PTM Bio

Cat# PTM-701

Goat anti Rabbit IgG H&L Polyclonal antibody, HRP conjugated

Abcam

Cat# ab6721; RRID:AB_955447

Goat anti-Mouse IgG H&L Secondary Antibody

Invitrogen

Cat# 31430; RRID: AB_228307

IL4, Clone 30340

Invitrogen

Cat# MA5-23722;RRID: AB_2609637

IL10, Clone JES5-16E3

Invitrogen

Cat# 16-7101-85; RRID: AB_469225

Rat IgG2b Isotype Control

Invitrogen

Cat# 02-9288; RRID: AB_2532966

Annexin V (Ann-V) purified recombinant protein

Invitrogen

Cat# BMS306

Recombinant Mouse IL4

Peprotech

Cat# 214-14; RRID: AB_2609637

Recombinant Mouse IL10

R&D systems

Cat# 417-ML

Recombinant Mouse TGF-beta 1 Protein

R&D systems

Cat# 7666-MB

Recombinant Mouse Insulin R/CD220 Protein

R&D systems

Cat# 7544-MR

Vismodegib

Topscience

Cat# T2590

iCRT3

Topscience

Cat# T4302

Semagacestat

Topscience

Cat# T6125

UNC2541

Topscience

Cat# T17205

Z-VAD-FMK

MCE

Cat# HY-16658B

I collagenase

Sigma

Cat# C0130

II Collagenase

Sigma

Cat# C6885

IV collagenase

Sigma

Cat# C5138

Pronase E

Sigma

Cat# 1.07433

DNase I

BioDuly

Cat# E0046

DAPI

Sigma

Cat# D5942

IMDM

Gibco

Cat# 12200036

DMEM

Gibco

Cat# 12800017

FBS

Gibco

Cat# 10091155

Percoll

GE Healthcare

Cat# 17-0891-01

Nycodenz

Axis-shield

Cat# 1002424

BeyoGel™SDS-PAGE Precast Gel (4%-15%)

Beyotime Biotechnology

Cat# P0057A

Trizol Reagent

Invitrogen

Cat# 15596026

iScript^TM RT-qPCR Sample Preparation Reagent

Bio-Rad

Cat# 170-8898

D-Luciferin

Shanghai Sciencelight Biology Science&Technology

Cat#luc001

Z-DEVD-aminoluciferin

Promega

Cat# P1782

CellTracker™ CM-DiI Dye

Beyotime Biotechnology

Cat# C7000

Sirius red

Sigma

Cat#365548 CAS: 2610-10-8

Oil Red O

Sigma

Cat# O0625 CAS: 1320-06-5

Toluidine blue

Sigma

Cat# 89640 CAS: 6586-04-5

Alizarin Red S

Sigma

Cat# A5533 CAS: 130-22-3

olive oil

Sangon Biotech

Cat# A502795; CAS: 8001-25-0

MMP12 Elisa Kit

Sangon Biotech

Cat# D721034

BCA protein assay kit

Beyotime Biotechnology

Cat# P0465S

123count eBeads™ Counting Beads

Invitrogen

Cat# 01-1234-42

Flow Cytometry Size Calibration Kit

Invitrogen

Cat# F13838

Hydroxyproline assay kit

NanJing Jiancheng Bioengineering Institute

Cat# A030-2-1

Alanine aminotransferase Assay Kit

NanJing Jiancheng Bioengineering Institute

Cat# C009-2

Dead Cell Apoptosis Kit with Annexin V FITC and PI

Invitrogen

Cat# V13242

DAB Horseradish Peroxidase Color Development Kit

Beyotime

Cat# P0202

L929

ATCC

Cat# CCL-1^TM

C57BL/6 J

GemPharmatech

Cat# N000013

C57B6/JGpt-Ccr2^em8Cd6657/Gpt

GemPharmatech

Cat# T006112

C57BL/6J-TgN (Chicken-β-actin-LUC) ZLFILAS

Sciencelight Biology Science&Technology

N/A

C57BL/6-Tg (CAG-EGFP)1Osb/J

The Jackson Laboratory

3291

GraphPad Prism 8

Graphpad Software

https://www.graphpad.com

Flowjo v10.5.0

Flowjo

https://www.flowjo.com

ImageJ

ImageJ software

https://imagej.nih.gov/ij

Image software

Carl Zeiss, Germany

N/A