Fig. 2: Compound 968 analogs exert synergistic inhibitory effects with ADR against MCF-7ADR cell viability. | Cell Death Discovery

Fig. 2: Compound 968 analogs exert synergistic inhibitory effects with ADR against MCF-7ADR cell viability.

From: Compound 968 reverses adriamycin resistance in breast cancer MCF-7ADR cells via inhibiting P-glycoprotein function independently of glutaminase

Fig. 2

A Chemical structure of compound 968. B Ninety-five analogs of compound 968 were synthesized and tested. MCF-7ADR cells were treated with compound 968 analogs (10 µM) combined with ADR (2 µM) for 48 h. Cell viability was detected using the CCK8 assays. C MCF-7ADR cells were treated with compound 968 or compound 968 analogs alone (2 µM), together with ADR (2 µM) for 48 h. Cell viability was detected using the CCK8 assays. D MCF-7 and MCF-7ADR cells were treated with compound 968 or compound 968 analogs (0, 1, 2, and 5 µM) for 48 h. Cell viability was detected using the CCK8 assays. All groups were compared with the compound 968-treated group. E Chemical structures of compound 968 analogs. Data are presented as mean ± SD of three independent experiments. ***P < 0.001, two-tailed Student’s t test.

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