Fig. 2: m6A modification of circARHGAP12 could increase its stability. | Cell Death Discovery

Fig. 2: m6A modification of circARHGAP12 could increase its stability.

From: IGF2BP2-modified circular RNA circARHGAP12 promotes cervical cancer progression by interacting m6A/FOXM1 manner

Fig. 2

A RT-PCR showed the circARHGAP12 expression in the cervical cancer cells (HT-3, CaSki, C33A, and SiHa). B m6A quantitative analysis detected the m6A enrichment in the cervical cancer cells (CaSki and SiHa) and normal cells (HaCaT). C MeRIP-PCR detected the circARHGAP12 enrichment in anti-m6A immunoprecipitation in cervical cancer (CaSki and SiHa) and normal cells (HaCaT). D Schematic diagram displayed the interaction within circARHGAP12 and IGF2BP2. E RNA stability assay illustrated the circARHGAP12 level in the IGF2BP2 overexpression group and control group. F MeRIP-PCR assay measured the circARHGAP12 expression in cervical cancer (CaSki, SiHa) transfected with IGF2BP2 overexpression. Experiments were performed in triplicate. P values were calculated by Student’s t-test. **p < 0.01.

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