Fig. 2: FBW7 decreases the occurrence of T1D in vivo and in vitro. | Cell Death Discovery

Fig. 2: FBW7 decreases the occurrence of T1D in vivo and in vitro.

From: Suppressive role of E3 ubiquitin ligase FBW7 in type I diabetes in non-obese diabetic mice through mediation of ubiquitination of EZH2

Fig. 2

A The diabetes incidence of each group. B The islet size of each group. C FBW7 expression in mice islet of each group determined by Western blot analysis. D FBW7 expression in induced splenocytes and pancreatic beta cells of each group was determined by Western blot analysis. E The levels of IL-17A, IL-2, IFN-γ, and IL-4 in cell supernatant of each group were determined by ELISA. F The pancreatic beta-cell apoptosis of each group was determined by flow cytometry. G The insulin secretion of each group. *p < 0.05, vs. the normal group, #p < 0.05, vs. the OE-NC group. All experiments were conducted in triplicate. Data comparisons between two groups were analyzed by unpaired t-test. Comparisons among multiple groups were performed by one-way ANOVA. Statistical analysis in relation to time-based measurements within each group was realized using repeated-measures ANOVA.

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