Fig. 7: Schematic diagram illustrating the action of NRMT on chemosensitivity of retinoblastoma cells via the CENPA-mediated Myc/Bcl2 axis. | Cell Death Discovery

Fig. 7: Schematic diagram illustrating the action of NRMT on chemosensitivity of retinoblastoma cells via the CENPA-mediated Myc/Bcl2 axis.

From: Knockdown of NRMT enhances sensitivity of retinoblastoma cells to cisplatin through upregulation of the CENPA/Myc/Bcl2 axis

Fig. 7

NRMT upregulates CENPA through histone methylation to promote the enrichment of CENPA on the Myc promoter region, by which Bcl2 expression is elevated so that chemosensitivity of retinoblastoma cells is suppressed.

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