Table 1 The dysregulated circRNAs in osteoporosis.
From: Circular RNAs in osteoporosis: expression, functions and roles
Gene symbol (circBase ID) | Function on osteoporosis | Expression | Downstream genes | PMID |
|---|---|---|---|---|
CDR1as (hsa_circ_0001946) | Inhibition | Upregulated during the osteogenic differentiation | miR-7/GDF5 | 30170617 |
CDK8 (hsa_circ_0003489) | Represses the osteogenic differentiation of PDLSCs | Increased in periodontitis tissues | / | 32978798 |
SIPA1L1 (hsa_circ_0102538) | Promote osteogenic differentiation | Down expressed in SCAPs during the osteogenic differentiation | miR-204-5p/ALPL | 33138854 |
Hmbox1 (hsa_circ_0083821) | Inhibit RANKL-induced osteoclasts differentiation | Reduced in TNF-α-induced osteoclast formation | miR-1247-5p/Bcl6 | 33425899 |
CSNK1G3 (hsa_circ_0127780) | Promotion | Upregulation | miR‐335/ Dkk‐1 | 30046991 |
YAP1 (hsa_circ_0024093) | Facilitate osteoblast differentiation in BMSC and MC3T3-E1 cells | Increased during differentiation of BMSC and MC3T3-E1 cells | miR-376b-3p/YAP1 | 32768931 |
circ_28313 | Promotion | Upregulation | / | 31204558 |
Dbf4 (mmu_circ_0001314) | Promote osteoclastogenesis | Increased during osteoclast differentiation | miR-5107/ TRAF6 | 32744684 |
ZNF720 (mmu_circ_0007059) | Circ_0007059 overexpression attenuated hBMSC differentiation into osteoclasts in vitro | Upregulated in patients with PM | miR-378/BMP2 | 33200464 |
circ_33287 | Promote the osteogenic differentiation of MSMSCS | Upregulated during the osteogenic differentiation of MSMSCS | / | 30551425 |
DNAH14 (hsa_circ_0016624) | Prevent osteoporosis | Downregulated in osteoporosis | miR-98/BMP2 | 31235259 |
MIDN (hsa_circ_0048211) | Alleviate the progression of PMOP | Downregulated in hBMSCs isolated from PMOP patients | miR-93-5p/BMP2 | 32329818 |
RUNX2 (hsa_circ_0076690) | Promote osteogenic differentiation | Decreased in osteoporosis patients | miR152/RUNX2 | 32717724 |
ZCCHC17 (hsa_circ_0011269) | Inhibit osteoporosis | Increased during osteogenic differentiation | miR-122/RUNX2 | 32619044 |
DYNC1H1 (hsa_circ_0002060) | Could be used as a potential diagnostic biomarker and therapeutic target in osteoporosis | Upregulated in osteoporosis patients | / | 31056800 |
PRIM2 (hsa_circ_0076906) | Relieved osteoporosis | Circ_0076906 silencing inhibited osteogenesis-related genes in hMSCs. | miR-1305/OGN | 32087327 |
PLCL2 (hsa_circ_0001275) | Potential diagnostic biomarker for PMOP | Upregulated in PMOP patients | / | 29742503 |
circ_SLC8A1 | Inhibition | Reduced in osteoporosis | miR-516b-5p/AKAP2 | 32830397 |
SLC4A7 (hsa_circ_0006215) | Overexpression of hsa_circ_0006215 promotes the osteogenic differentiation of BMSCs. | Downregulated in BMSCs from patients with OP | miR-942-5p/RUNX2, VEGF | 33819188 |
SMARCA5 (hsa_circ_0001445) | A novel biomarker for osteoporosis | Much lower in OPO patients compared with healthy controls | / | 33140658 |
RPL41 (hsa_circ_0026827) | Promote osteoblast differentiation of DPSCs | Increased during osteoblast differentiation | miR-188-3p/Beclin1, RUNX1 | 32671065 |
ENC1 (hsa_circ_0006859) | Suppress osteoblastic differentiation | Upregulated in osteoporosis patients | miR-431-5p/ROCK1 | 33648601 |
Tssc1 (mmu_circ_0003865) | Inhibit osteoporosis | Decreased by MEL treatment | miR-3653-3p/ GAS1 | 33632317 |
CD44 (hsa_circ_0021739) | Inhibited the differentiation of osteoclasts | Downregulated in patients with postmenopausal osteoporosis | miR-502-5p | 33875631 |
REV1 (hsa_circ_0001052) | miR-124-3p | 33884524 |
