Fig. 1: Classification of tsRNAs. | Cell Death Discovery

Fig. 1: Classification of tsRNAs.

From: tRNA-derived small RNAs: novel regulators of cancer hallmarks and targets of clinical application

Fig. 1: Classification of tsRNAs.The alternative text for this image may have been generated using AI.

tRF-1s are derived from the 3′-end of the precursor tRNA. tRF-5s are derived from the 5′-end of mature tRNAs and end at a D-loop or at a stem region between the D-loop and the anti-codon loop. tRF-3s are generated from the TψC loop with a “CCA” tail. tRF-2s are produced by decomposition of the anticodon loop of tRNA and do not include the typical 5′-end and 3′-end groups. i-tRFs are generated from the internal region of mature tRNAs straddling the anti-codon region with variable length. tiRNAs are almost half the length of mature tRNAs.

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