Fig. 4: Effect of DNMT-1 on autophagy-ferroptosis axis in myocardial tissue. | Cell Death Discovery

Fig. 4: Effect of DNMT-1 on autophagy-ferroptosis axis in myocardial tissue.

From: Inhibition of DNMT-1 alleviates ferroptosis through NCOA4 mediated ferritinophagy during diabetes myocardial ischemia/reperfusion injury

Fig. 4

A The changes of autophagosome in myocardial tissue were detected by electron microscopy. B Fe2+ in myocardial tissue was detected. C ROS in myocardial tissue was detected. D–F The protein expression of DNMT-1, NCOA4, FTH, GPX4, Beclin-1, and p62 in myocardial tissue was detected by western blotting. G The expression of NCOA4 in myocardial tissue was detected by IHC. Results are presented by means ± SD. n = 8 per group. #P < 0.05 compared with the DS group. *P < 0.05 compared with the DIR group.

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