Fig. 8: Effect of DNMT-1 on the autophagy-ferroptosis axis of HH/R H9c2 cells through NCOA4. | Cell Death Discovery

Fig. 8: Effect of DNMT-1 on the autophagy-ferroptosis axis of HH/R H9c2 cells through NCOA4.

From: Inhibition of DNMT-1 alleviates ferroptosis through NCOA4 mediated ferritinophagy during diabetes myocardial ischemia/reperfusion injury

Fig. 8

A The protein expression of NCOA4 was detected by western blotting. B Cell viability was detected by CCK-8. C–F LDH, Fe2+, GSH, cellular ROS production was detected. The protein expression of NCOA4, FTH, GPX4, Beclin-1, and p62 in H9c2 cells was detected by western blotting. Results are presented by means ± SD. n = 6 per group. #P < 0.05 compared with the HG group. *P < 0.05 compared with the HH/R group. ※P < 0.05 compared with the HH/R + NCOA4-siRNA group.

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