Fig. 6: Upregulated TIPE promotes CRC tumor growth in vivo by GPX4-induced ferroptosis inhibition. | Cell Death Discovery

Fig. 6: Upregulated TIPE promotes CRC tumor growth in vivo by GPX4-induced ferroptosis inhibition.

From: miR-539 activates the SAPK/JNK signaling pathway to promote ferropotosis in colorectal cancer by directly targeting TIPE

Fig. 6: Upregulated TIPE promotes CRC tumor growth in vivo by GPX4-induced ferroptosis inhibition.

a Representative images of the TIPE+/+ and vector groups xenograft tumors and the weights of the xenograft tumors from the TIPE+/+ and vector groups. b The volume of the xenograft tumor from the TIPE+/+ and vector groups was calculated every 2 days after inoculation for 2 weeks. p < 0.0001. c TIPE, miR-539 and GPX4 expression in the TIPE+/+ and vector groups was analyzed by RT-qPCR. d Representative images of the TIPE and GPX4 expression in the TIPE+/+ and vector groups was analyzed by IHC. e The expression levels of TIPE, GPX4, p-SAPK/JNK and p53 in the TIPE+/+ and vector groups were measured with western blot analysis. Data are presented as the mean ± SD. **p < 0.01; ****p < 0.0001.

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