Table 1 Overview of deregulated lncRNAs in BCa.
From: Biological functions and clinical significance of long noncoding RNAs in bladder cancer
LncRNA | Expression | Target | Functions | Ref./PMID | |
|---|---|---|---|---|---|
Promotion | Inhibition | ||||
AC114812.8 | ↑ | miR-371b-5p/FUT4 | Proliferation, migration, invasion, and EMT | 31706102 | |
ADAMTS9-AS2 | ↓ | Proliferation, migration and invasion | 32801743 | ||
AFAP1-AS1 | ↑ | Proliferation and invasion | 32964963 | ||
ANRIL | ↑ | Proliferation | Apoptosis | 26449463 | |
ARAP1-AS1 | ↑ | miR-4735-3p/NOTCH2 | Proliferation and migration | Migration | 30404578 |
ARSR | ↑ | miR-129-5p/SOX4 | Proliferation, migration, and invasion | 31892841 | |
ASAP1-IT1 | ↑ | Stemness | 28895409 | ||
ATB | ↑ | miR-126/KRAS | Proliferation, migration, and invasion | 29321082 | |
BCAR4 | ↑ | miR-370-3p/miR-644a/TLX1 | Proliferation, migration and invasion | Apoptosis | 31894304 32273720 |
BRE-AS1 | ↓ | STAT3 | Apoptosis | Proliferation | 32495865 |
CALML3-AS1 | ↑ | ZBTB2/miR-4316 | Proliferation, migration, and invasion | 30177388 | |
CARLo-7 | ↑ | Proliferation, migration, invasion, and EMT | 33209690 | ||
CASC11 | ↑ | miR-150 | Proliferation | 30916832 | |
CASC9 | ↑ | miR-497-5p/FZD6 miR-758-3p/TGF-β2 | Proliferation, migration, invasion, and EMT | 32677984 33200222 | |
CASC9 | ↑ | STAT3/EZH2/PTEN | Proliferation, migration, and invasion | 32982303 | |
CCAT1 | ↑ | Proliferation, migration and invasion | 31038865 | ||
CDKN2B-AS1 | ↑ | Gemcitabine sensitivity | 29937935 | ||
CRNDE | ↑ | Migration and proliferation | Apoptosis | 29710461 | |
DANCR | ↑ | miR-149/MSI2 | Proliferation, migration, and invasion | 30419948 | |
DBCCR1-003 | ↓ | DBCCR1/DNMT1 | Cell cycle, apoptosis, and DNA methylation | 27777512 | |
DDX11-AS1 | ↑ | miR-2355-5p/LAMB3 | Proliferation | 32412777 | |
DGCR5 | ↓ | ARID1A/P21 | Apoptosis | Proliferation, colony formation, cell cycle, migration, invasion, and EMT | 30238982 |
DLEU1 | ↑ | miR-99b/HS3ST3B1 | Proliferation, invasion, and cisplatin resistance | 30984249 | |
DLX6-AS1 | ↑ | miR-223/HSP90B1 miR-195-5p/VEGFA | Proliferation, Invasion, migration and EMT | 31615303 31787849 32756011 | |
EGFR-AS1 | ↑ | miR-381/ROCK2 | Invasion and migration | 32194685 | |
ELF3-AS1 | ↑ | KLF8 | Viability and migration | 30528231 | |
FAM83H-AS1 | ↑ | ULK3 | Proliferation, migration, invasion, EMT and angiogenesis | Apoptosis | 33289601 |
FOXD2-AS1 | ↑ | TRIB3/AKT/E2F1 miR-143/ABCC3 | Proliferation, migration, invasion, and gemcitabine resistance | 29445134 29674277 | |
GAS5 | ↓ | CDK6, CCL1 | Proliferation and doxorubicin resistance | 24069260 26548923 27878359 | |
GAS6-AS2 | ↑ | miR-298/CDK9 | Proliferation and metastasis | 30394665 | |
GClnc1 | ↑ | LIN28B/let-7a/MYC | Proliferation, migration, and invasion | 31298933 | |
GHET1 | ↑ | ABCC1 | Gemcitabine resistance | 31115606 | |
H19 | ↑ | miR-29b-3p/DNMT3B EZH2/E-cad | Proliferation, invasion, migration, metastasis, and EMT | 23354591 28779971 | |
HCG18 | ↓ | miR-34c-5p/NOTCH1 | Proliferation and migration | 30426533 | |
HCG22 | ↓ | PTBP1 | Proliferation, migration, invasion and EMT | 31304601 | |
HCP5 | ↑ | miR-29b-3p/HMGB1/TLR4 | Viability, proliferation migration and invasion | 33235469 | |
HIF1A-AS2 | ↑ | HMGA1/P53 | Cisplatin resistance | 30216500 | |
HNF1A-AS1 | ↑ | Proliferation, migration, and invasion | 29541223 | ||
HOTAIR | ↑ | miR-205/CCNJ | Proliferation, migration and invasion | Chemosensitivity to doxorubicin and cell apoptosis | 26469956 26781446 |
HOXA-AS2 | ↑ | miR-125b/Smad2 | Migration, invasion and stemness | 30412716 | |
HULC | ↑ | ZIC2 | Proliferation | Apoptosis | 28946549 |
IGFBP4-1 | ↑ | Proliferation and cell cycle | Apoptosis | 32760196 | |
ITGB1 | ↑ | miR-10a | Proliferation | 31486485 | |
KCNQ1OT1 | ↑ | miR-145-5p/PCBP2 miR-218-5p/HS3ST3B1 | Proliferation, migration, invasion and EMT | Apoptosis | 31827399 32820233 |
KTN1-AS1 | ↑ | KTN1 | Proliferation, invasion, and migration | 33480975 | |
LBCS | ↓ | SOX2 | Self-renewal and chemoresistance | 30397178 | |
LET | ↓ | NF90/miR-145 | Gemcitabine chemoresistance and stemness | 28839463 | |
LINC00162 | ↑ | PTTG1IP/THRAP3 | Proliferation | Apoptosis and G0/G1 phase block | 33344916 |
LINC00319 | ↑ | miR-4492/ROMO1 miR-3127/RAP2A | Proliferation, migration and invasion | 31608995 32194636 | |
LINC00346 | ↑ | Proliferation and migration | Cell cycle and apoptosis | 28705739 | |
LINC00460 | ↑ | Proliferation and migration | 30881506 | ||
LINC00511 | ↑ | miR-15a-3p | Proliferation, migration, and invasion | Apoptosis | 30042171 |
LINC00612 | ↑ | miR-590/PHF14 | Proliferation, invasion, and EMT | 30940184 | |
LINC00641 | ↓ | miR-197-3p/KLF10/PTEN | Proliferation migration, and invasion | 30060954 | |
LINC00675 | ↓ | Migration, invasion, and proliferation | 32367602 | ||
LINC00857 | ↑ | LMAN1 | Platinum-based chemotherapy resistance | 29856124 | |
LINC01106 | ↑ | miR-3612/ELK3 DKC1/HOXD8 | Proliferation, migration, invasion, and EMT | 33311496 | |
LINC01140 | ↑ | miR-140-5p/FGF9 | Cell aggressiveness and macrophage M2 olarization | 33234721 | |
LINC01296 | ↑ | Proliferation, cell cycle, migration, and EMT | 30588032 | ||
LINC01605 | ↑ | MMP9 | Proliferation, migration, and invasion | 30054424 | |
LINC01638 | ↑ | ROCK2 | Migration and invasion | 31620199 | |
LOC572558 | ↓ | AKT/MDM2/P53 | Cell cycle arrest and apoptosis | Proliferation, migration and invasion | 27130667 |
LSINCT5 | ↑ | NCYM | Tumor sphere formation and EMT process | 29772237 | |
MAFG-AS1 | ↑ | HuR/PTBP1 miR-143-3p/COX-2 miR-125b-5p/SphK1 | Proliferation, migration, invasion, metastasis, and EMT | 33238264 33377647 33400245 | |
MAGI2-AS3 | ↓ | miR-15b-5p/CCDC19 miR-31-5p/TNS1 MAGI2/PTEN | Proliferation, migration, invasion, and EMT | 30442369 33104021 33231563 | |
MALAT1 | ↑ | miR-125b/SIRT7 miR-125b/Bcl-2/MMP-13 SUZ12 miR-124/FOXQ1 miR-101-3p/VEGF-C | Proliferation, migration, invasion, EMT, and cisplatin resistance | Apoptosis | 24449823 24512850 29151968 29736319 31650173 |
MBNL1-AS1 | ↓ | miR-135a-5p/PHLPP2/FOXO1 MiR-362-5p/QKI | Apoptosis | Proliferation | 31769229 32194406 |
MEG3 | ↓ | miR-96/TPM1 P53 | Apoptosis and cisplatin chemosensitivity | Proliferation, cell cycle, migration, and invasion | 23295831 29940769 30461333 |
MIR143HG | ↓ | miR-1275/AXIN2 | Proliferation, cell cycle, migration, and invasion | 30471109 | |
MIR497HG | ↓ | E2F4 | Cell growth, migration, and invasion | 33363213 | |
MIR503HG | ↓ | Apoptosis and cell cycle | Proliferation, cell growth, cell invasion, migration, and EMT | 30672010 | |
MNX1-AS1 | ↑ | miR-218-5p/RAB1A | Proliferation, migration, invasion, and EMT | 31843814 | |
MORT | ↓ | miR-146a-5p | Migration, proliferation, and invasion | 32554962 | |
MST1P2 | ↑ | miR-133b | Chemoresistance to DDP | 32052927 | |
MT1JP | ↓ | miR‐214‐3p | Proliferation, cell-cycle, and invasion | 30786017 | |
NCK1-AS1 | ↑ | miR-143 | Proliferation and stemness | 32184669 | |
NEAT1 | ↑ | miR-410/HMGB1 | Proliferation | Apoptosis | 31734579 |
NNT-AS1 | ↑ | miR-1301-3p/PODXL | Proliferation, migration, invasion and EMT | 31782983 | |
NRON | ↑ | Proliferation, migration, invasion, and EMT | 32194786 | ||
OIP5-AS1 | ↑ | OIP5 | Proliferation, cell viability, and cell‐cycle | Apoptosis | 30485498 |
OXCT1‐AS1 | ↑ | miR-455-5p/JAK1 | Proliferation and invasion | 30609030 | |
PANDAR | ↑ | Proliferation and migration | Apoptosis | 27206339 | |
PART1 | ↑ | Proliferation and invasion | Apoptosis | 31311442 | |
PCAT6 | ↑ | miR-513a-5p | Viability, migration, and invasion | 33090394 | |
PEG10 | ↑ | miR-29b miR-134/LRP6 | Proliferation, migration, and invasion | Apoptosis | 30941768 30953817 |
PLAC2 | ↓ | miR-663/TGF-β1 | Invasion and migration | 32650766 | |
PlncRNA-1 | ↑ | miR-136/smad3 | Proliferation, migration, and invasion | 33288752 | |
PTENPL | ↑ | MiR-20a/PDCD4 | Proliferation and migration | 32271413 | |
PVT1 | ↑ | miR-128/VEGFC miR-194-5p/BCLAF1 miR-31/ CDK1 | Proliferation, invasion and migration | Apoptosis | 30076714 30317572 33188158 |
RMRP | ↑ | miR-206 | Proliferation, migration, and invasion | 30779067 | |
RNF144A-AS1 | ↑ | miR-455-5p/SOX11 | Proliferation, migration, and invasion | 33177836 | |
ROR1-AS1 | ↑ | miR-504 | Proliferation and migration | 31929567 | |
RP11-79H23.3 | ↓ | miR-107/PTEN | Apoptosis | Proliferation, migration, cell-cycle, lung metastasis, and angiogenesis | 30149689 |
SLCO4A1-AS1 | ↑ | miR-335-5p/OCT4 | Proliferation, migration, and invasion | 30863101 | |
SNHG1 | ↑ | miR-143-3p/EZH2 | Proliferation, migration, and invasion | 32885590 | |
SNHG14 | ↑ | miR-211-3p/ESM1 | Cell cycle, colony formation, invasion, migration and proliferation | Apoptosis | 33482820 |
SNHG16 | ↑ | miR-98/STAT3 P21 miR-200a-3p/ZEB1/ZEB2 | Proliferation, migration, invasion, and EMT | Apoptosis and cell cycle | 29234154 30132983 32207096 |
SNHG20 | ↑ | Proliferation, colony formation, migration and invasion | Apoptosis | 30106094 | |
SNHG3 | ↑ | miR-515-5p/GINS2 | Proliferation, migration, invasion, and EMT | 32596993 | |
SNHG5 | ↑ | p27 | Proliferation and cell cycle | Apoptosis | 29434891 |
SNHG6 | ↑ | miR‐125b/Snail1/2/NUAK1 | Migration, invasion, and EMT | 30168179 | |
SNHG7 | ↑ | miR-2682-5p/ELK1 | Proliferation, cell viability, proliferation, cell cycle, migration, invasion, and EMT | Apoptosis | 30003751 30527358 30719150 32898531 |
SOX2OT | ↑ | miR-200c/SOX2 | Migration, invasion, EMT, and stemness | 32019566 | |
SPRY4-IT1 | ↑ | miR-101-3p/EZH2 | Proliferation, migration, and invasion | Apoptosis | 27998761 |
TINCR | ↑ | miR-7/mTOR | Proliferation, migration, and invasion | 33000269 | |
TMPO-AS1 | ↑ | miR-98-5p/EBF1 TMPO | Proliferation, migration and invasion | Apoptosis | 32087328 32964962 |
TP73-AS1 | ↓ | Apoptosis | Cell growth, cell cycle, migration, invasion, and EMT | 29625110 | |
TUC338 | ↑ | miR-10b | Migration and invasion | 31162712 | |
TUG1 | ↑ | miR-145/miR-142/ZEB2 miR-29c HMGB1 miR-194-5p/CCND2 Nrf2 | Proliferation, migration, invasion, cisplatin resistance, radioresistance, and EMT | Apoptosis, radiosensitivity, and sensitivity of Adriamycin | 26318860 28376901 28503069 29321088 30925453 31308746 |
UCA1 | ↑ | miR-196a-5p/CREB C/EBPα mTOR-STAT3/miR-143 BRG1 miR-16/GLS2 miR-145/ZEB1/2/FSCN1 miR-143/HMGB1 BMP9 miR-582-5p/ATG7 | Cell proliferation, migration, invasion, EMT, glycolysis, mitochondrial glutaminolysis, Cisplatin/gemcitabine resistance | Apoptosis and ROS production | 22285928 24495014 24648007 24890811 24993775 26373319 26544536 27591936 28841829 29113184 29642505 30666128 |
UCA1a(CUDR) | ↑ | Proliferation, migration, and invasion | Apoptosis | 22576688 | |
XIST | ↑ | miR-200c miR-133a P53/TET1 | Proliferation, cell clone formation, self-renewal, EMT, stemness, and migration | Apoptosis | 29559853 30362292 31602223 |
ZEB1-AS1 | ↑ | miR-200b/FSCN1/TGF-β1 ZEB1/AUF1 | Proliferation, migration, invasion, and metastasis | Apoptosis | 30823924 31115480 |
ZEB2-AS1 | ↑ | miR-27b | Proliferation | Apoptosis | 28992472 |
ZFAS1 | ↑ | miR-329 KLF2/NKD2 ZEB1/ZEB2 | Proliferation, colony formation, cell cycle, migration, and invasion | Apoptosis | 29653362 29678899 |
ZNF503-AS1 | ↓ | SLC8A1/GATA6 | The intracellular Ca2+ concentration and cell apoptosis | Proliferation, invasion and migration | 33001357 |
ZNFX1-AS1 | ↑ | miR-193a-3p/SDC1 | Proliferation, cell clone formation, migration, and invasion | 32432735 | |
ZNRD1-AS1 | ↑ | miR-194/ZEB1 | Proliferation, migration, invasion, and EMT | 32862492 | |
