Fig. 5: MYH9 regulates the stem phenotype of LCCs by activating the mTOR signaling pathway. | Cell Death Discovery

Fig. 5: MYH9 regulates the stem phenotype of LCCs by activating the mTOR signaling pathway.

From: MYH9 is crucial for stem cell-like properties in non-small cell lung cancer by activating mTOR signaling

Fig. 5: MYH9 regulates the stem phenotype of LCCs by activating the mTOR signaling pathway.The alternative text for this image may have been generated using AI.

A The protein expression of LRP6/GSK3/mTOR signal pathway markers in MYH9 stable transformant and control cells. B The expression of proteins from PI3K/AKT/mTOR signaling pathway in MYH9 stable transgenic and control cells. C Analysis of the effect of mTOR inhibitor Rapamycin on the self-renewal ability of MYH9 overexpressing cells and control cells (scale bar, 100 μm; n = 3; *p < 0.05; n.s., not significant; Student’s t-test). D The effect of GSK3 inhibitor CHIR–99021 on MYH9 low expression cell self-renewal ability and control cells (scale bar, 100 μm; n = 3; *p < 0.05and **p < 0.01; Student’s t-test).

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