Fig. 6: piR-57125 inhibits ccRCC metastasis via the AKT/ERK pathway. | Cell Death Discovery

Fig. 6: piR-57125 inhibits ccRCC metastasis via the AKT/ERK pathway.

From: PIWI-interacting RNA 57125 restrains clear cell renal cell carcinoma metastasis by downregulating CCL3 expression

Fig. 6

a Western blot assay showed the elevated or decreased expression of p-AKT and p-ERK1/2 upon knockdown or overexpression of piR-57125 in 786-O and OSRC-2 cells. b, c Western blot assay showed that the expression of p-AKT and p-ERK1/2 was decreased (b) or elevated (c) in ccRCC cells through transfected CCL3 siRNAs (b) or added rhCCL3 (c). d, e Western blot assay demonstrated that the increased d or decreased e expression of p-AKT and p-ERK1/2 induced by piR-57125 inhibitors d or mimics e could be reversed by CCL3 siRNAs (d) or rhCCL3 e.

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