Fig. 4: De-escalation antibiotic therapy modulated the formation of NETs during sepsis. | Cell Death Discovery

Fig. 4: De-escalation antibiotic therapy modulated the formation of NETs during sepsis.

From: De-escalation antibiotic therapy alleviates organ injury through modulation of NETs formation during sepsis

Fig. 4

A, B The liver and intestine tissues collected in each group were treated with the IHC examination. Severer liver and intestine injuries were correlative to more positive citH3 and apoptotic cells in these tissues. The de-escalation group had milder liver and intestine injuries and lower NETs than the escalation group. C At the early stage of sepsis (Day 3), blood was drawn from different groups (n = 25), and serum MPO-DNA levels were determined with a mouse MPO ELISA kit. DE group showed higher serum MPO-DNA levels than the ES group, and both were lower than the control group (p < 0.001). Higher MPO-DNA levels were diminished with the administration of DNase I (p < 0.001). D At the late stage of sepsis (Day 6), serum MPO-DNA levels were determined the same way (n = 20). The ES group showed higher levels of serum MPO-DNA than the DE group (p < 0.01), and both were higher than the sham group (p < 0.001). DE de-escalation. ES escalation.

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