Fig. 5: De-escalation strategy caused less organ injuries and inflammatory response attenuated by DNase I in the early sepsis stage. | Cell Death Discovery

Fig. 5: De-escalation strategy caused less organ injuries and inflammatory response attenuated by DNase I in the early sepsis stage.

From: De-escalation antibiotic therapy alleviates organ injury through modulation of NETs formation during sepsis

Fig. 5

A, B The serum AST and Creatine were determined by ELISA (n = 25). Reduced levels of AST and Creatine were shown in DE compared with the ES group (p < 0.01), however, this effect was reversed by NETs scavenger, DNase I (p < 0.001). C–F The serum levels of IL-6, IFN-γ, IL-10, and MCP-1 were determined using Luminex® xMAP (n = 25). The inflammatory cytokines levels were lower in the DE group than that in the ES group (p < 0.01), except for the level of MCP-1 (p < 0.001). When DNase I was administrated, all were elevated compared with the DE group (p < 0.05). DE de-escalation. ES escalation.

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