Fig. 3: GSK 872, the inhibitor of RIPK3 reduces cell death in pHCECs. | Cell Death Discovery

Fig. 3: GSK 872, the inhibitor of RIPK3 reduces cell death in pHCECs.

From: Receptor interacting protein 3 kinase, not 1 kinase, through MLKL-mediated necroptosis is involved in UVA-induced corneal endothelium cell death

Fig. 3

A Flow chart of pHCECs treatment and UVA irradiation model. B, C LDH and Cell viability of pHCECs treated with vehicle DMSO (30 μM), RIPK1 inhibitor Nec-1 (15 and 30 μM), CASPASE inhibitor Z-VAD (15 and 30 μM), combination of Nec-1 and Z-VAD (15 and 30 μM), RIPK3 inhibitor GSK 872 (2.5 and 5 μM) after non-UVA and UVA irradiation (n = 6 per group). Statistical significance was analyzed with the unpaired Student’s t-test. **P < 0.01, ***P < 0.001, ****P < 0.0001. All values are expressed as mean ± SD.

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