Fig. 1: Expression and prognostic significance of SPTBN2 in UCEC.
From: SPTBN2 regulated by miR-424-5p promotes endometrial cancer progression via CLDN4/PI3K/AKT axis
a Volcano of differential genes in UCEC and nontumor tissues from TCGA UCEC database. b, c SPTBN2 mRNA expression analysis in UCEC and nontumor tissues in TCGA database (b) and GSE17025 (c). d SPTBN2 protein expression analysis according to CPTAC database. e The mRNA expression of SPTBN2 in 24 paired EEC tissues and adjacent normal tissues. f, g Representative IHC images of SPTBN2 expression in EEC and normal tissue (g). IHC score for SPTBN2 in 60 EEC samples and 25 endometrial normal samples (f). h High expression of SPTBN2 was associated with poor overall survival of UCEC patients based on TCGA database. i SPTBN2 protein expression was detected by western blot in six paired EEC tissues and adjacent normal tissues from EEC patients. C1-C6, represented EEC tissues; N1-N6, represented adjacent normal tissues. (*p < 0.05, **p < 0.01, ***p < 0.001, ****P < 0.0001. The data expressed as the mean ± SD).
